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Jun 9, - Pain is the first and most common symptom of thumb arthritis. Pain can occur at the base of your thumb when you grip, grasp or pinch an object, or use your thumb to apply force. Swelling, stiffness and tenderness at the base of your thumb. Decreased strength when pinching or grasping objects. Jul 9, - Numbness or tingling of fingers and thumb can happen for many reasons. Learn about the neuroanatomy of the hand and problems that lead to.