May 17, - If your semen quality can be optimized to a sperm count of 20 million, you may want to look for . Low testosterone results in lower sperm counts. Tricyclic antidepressants such as Elavil (Amitriptyline), Tofranil (Imipramine). Effects of amitriptyline on semen of infertile men. A clinical evaluation of the effects of the antidepressive drug amitriptyline on the semen of 20 infertile men with oligoasthenozoospermia was carried out. It would seem that amitriptyline has a beneficial effect on semen in some of these patients.