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Jul 1, - Most anal cancers are treated with a combination of radiotherapy and chemotherapy, which is known as chemoradiotherapy. Surgery may also. The 5-year survival rate for locally advanced anal cancer is 61%. If the cancer has spread to other parts of the body, it's called metastatic cancer. The 5-year survival rate for metastatic anal cancer is about 30%. The overall 5-year survival rate for anal cancer is about 66%.